CAS No. 21561-09-1
Batch:
Purity:99.64
Chemical Structure
Check the
WHI-P258
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6,7-dimethoxy-N-phenylquinazolin-4-amine | |
|---|---|---|
| CAS Number | 21561-09-1 | |
| Molecular Formula |
C16H15N3O2 |
|
| Molecular Weight (MW) | 281.31 | |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC=C3)OC | |
| InChIKey | MJKCGAHOCZLYDG-UHFFFAOYSA-N |
WHI-P258 is a synthetic dimethoxyquinazoline derivative that acts as a Janus kinase 3 (JAK3) inhibitor with a Ki value of 72 μM. By targeting JAK3, WHI-P258 suppresses the JAK/STAT signaling pathway, preventing the phosphorylation and activation of downstream STAT proteins. This inhibition blocks cytokine-mediated signal transduction, impairing lymphocyte activation, proliferation, and immune cell responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(49.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.