CAS No. 2941088-96-4
Chemical Structure
Check the
WH244
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,4R)-1-[(2S)-2-[[2-[4-[2-[4-[[(1R)-4-(4-chlorophenyl)-1-methyl-3-[[4-[4-[[4-[[(2R)-4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylcarbamoyl]phenyl]piperazin-1-yl]methyl]cyclohex-3-en-1-yl]methyl]piperazin-1-yl]-2-oxoethyl]piperazin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2941088-96-4 | |
| Molecular Formula | ||
| InChIKey | BSXCOLDAQWGIQN-ZNQYNWELSA-N |
WH244 is a second-generation proteolysis targeting chimera (PROTAC) that selectively degrades the anti-apoptotic proteins BCL-xL and BCL-2. Targeted degradation of these anti-apoptotic factors impairs BCL-2 family-mediated cell survival signalling, leading to the activation of mitochondrial apoptotic pathways, loss of mitochondrial membrane potential, and downstream induction of programmed cell death in target cancer cells. [1]
Note: Technical data last updated: Sep 1, 2026.