CAS No. 1431866-33-9
Chemical Structure
Check the
WEHI-539
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid | |
|---|---|---|
| CAS Number | 1431866-33-9 | |
| Molecular Formula |
C31H29N5O3S2 |
|
| Molecular Weight (MW) | 583.73 | |
| SMILES | C1CC2=C(C=C(C=C2)C3=NC(=C(S3)CCCOC4=CC=C(C=C4)CN)C(=O)O)C(=NNC5=NC6=CC=CC=C6S5)C1.Cl | |
| InChIKey | JKMWZKPAXZBYEH-JWHWKPFMSA-N |
Biological Activity
WEHI-539 is a highly potent and selective BCL-XL inhibitor displaying over 400-fold selectivity for BCL-XL relative to other prosurvival BCL-2 family proteins. By selectively antagonizing the prosurvival function of BCL-XL, WEHI-539 disrupts anti-apoptotic complexes, triggering the mitochondrial intrinsic apoptotic pathway and potently inducing cell death in BCL-XL-dependent cancer cell lines. [1]
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Note: Technical data last updated: Sep 1, 2026.