CAS No. 524-12-9

Batch: Purity:99.93
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Wedelolactone Chemical Structure
Chemical Structure
Check the Wedelolactone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
CAS Number 524-12-9
Molecular Formula

C16H10O7
Molecular Weight (MW) 314.25
SMILES COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O
InChIKey XQDCKJKKMFWXGB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Wedelolactone is a plant-derived natural compound that acts as a potent inhibitor of IκB kinase (IKK) and caspase-11. By inhibiting IKK activity, wedelolactone prevents the phosphorylation and degradation of IκBα, thereby blocking the activation and nuclear translocation of the NF-κB signaling pathway. This disruption of NF-κB signaling leads to suppressed inflammatory responses and reduced expression of downstream pro-inflammatory mediators in cellular models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1.5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.