CAS No. 1123231-07-1
Batch:
Purity:99.66
Chemical Structure
Check the
WAY-262611
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [1-(4-naphthalen-2-ylpyrimidin-2-yl)piperidin-4-yl]methanamine | |
|---|---|---|
| CAS Number | 1123231-07-1 | |
| Molecular Formula |
C20H22N4 |
|
| Molecular Weight (MW) | 318.42 | |
| SMILES | NCC1CCN(CC1)C2=NC=CC(=N2)C3=CC=C4C=CC=CC4=C3 | |
| InChIKey | QHLITPHIARVDJI-UHFFFAOYSA-N |
WAY-262611 is a Dickkopf-1 (DKK1) inhibitor and β-catenin agonist that enhances canonical Wnt signaling. By counteracting DKK1-mediated repression of the Wnt co-receptor complex, WAY-262611 facilitates β-catenin stabilization and TCF-mediated transcriptional activation. This downstream signaling promotes osteoblast differentiation and increases bone formation, making WAY-262611 a valuable probe for modulating Wnt-dependent skeletal biology. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(200.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 10 mg/mL |
| Ethanol | 10 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.