CAS No. 909725-61-7
Batch:
Purity:99.53
Chemical Structure
Check the
W146
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid | |
|---|---|---|
| CAS Number | 909725-61-7 | |
| Molecular Formula |
C16H27N2O4P |
|
| Molecular Weight (MW) | 342.37 | |
| InChIKey | FWJRVGZWNDOOFH-OAHLLOKOSA-N |
W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1). By targeting S1PR1, W146 blocks sphingosine-1-phosphate-mediated receptor activation and downstream signaling pathways involved in vascular endothelial function. Inhibition of S1PR1 by W146 compromises vascular barrier integrity, resulting in increased capillary leakage, altered endothelial cell responses, and enhanced vascular permeability in preclinical models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(198.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 34 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.