CAS No. 21093-51-6
Batch:
Purity:98.56
Chemical Structure
Check the
W-84 Dibromide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 21093-51-6 | |
|---|---|---|
| Molecular Formula |
C32H44N4O4.2Br |
|
| Molecular Weight (MW) | 708.52 | |
| SMILES | [Br-].[Br-].C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=C(C=CC=C2)C1=O)CCCN3C(=O)C4=C(C=CC=C4)C3=O |
Biological Activity
W-84 dibromide (HDMPPA) is a potent allosteric modulator of muscarinic M2 acetylcholine receptors. It retards N-methylscopolamine dissociation from the receptor and stabilizes cholinergic antagonist-receptor complexes. Through binding at the common extracellular allosteric site on M2 muscarinic receptors, W-84 modulates orthosteric ligand binding kinetics and alters downstream cholinergic signaling pathways to prevent receptor overstimulation. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 4 mg/mL |
| DMSO |
3 mg/mL
(4.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.