CAS No. 1476074-39-1
Batch:
Purity:98.65
Chemical Structure
Check the
VX-984
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 8-[(2S)-1-[[6-(4,6-dideuterio-2-methylpyrimidin-5-yl)pyrimidin-4-yl]amino]propan-2-yl]-N-methylquinoline-4-carboxamide | |
|---|---|---|
| CAS Number | 1476074-39-1 | |
| Molecular Formula |
C23H21D2N7O |
|
| Molecular Weight (MW) | 415.49 | |
| InChIKey | PEACIOGDEQRHFA-KIYKJNLWSA-N |
Biological Activity
VX-984 (M9831) is an orally active, potent, selective, and ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). By inhibiting DNA-PK, it suppresses non-homologous end joining repair, blocks DNA-PKcs autophosphorylation, and causes the accumulation of DNA double-strand breaks. Consequently, VX-984 enhances the cytotoxic and radiosensitizing effects of ionizing radiation in various cancer models, including non-small cell lung cancer.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(24.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.