CAS No. 1793080-72-4

Batch: Purity:98.03
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VX-150 Chemical Structure
Chemical Structure
Check the VX-150 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [4-[[2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzoyl]amino]-2-oxo-1-pyridinyl]methyl dihydrogen phosphate
CAS Number 1793080-72-4
Molecular Formula

C21H17F4N2O7P
Molecular Weight (MW) 516.34
SMILES CC1=C(OC2=C(C=CC(=C2)C(F)(F)F)C(=O)NC3=CC(=O)N(CO[P](O)(O)=O)C=C3)C=CC(=C1)F
InChIKey SQDQNNKQTHOQHO-UHFFFAOYSA-N

Ordering Information

Biological Activity

VX-150 is an orally bioavailable prodrug that converts into an active moiety acting as a selective inhibitor of voltage-gated sodium channel NaV1.8. Selective inhibition of NaV1.8 blocks action potential firing in peripheral nociceptive sensory neurons, suppressing nociceptive signal propagation along pain pathways. This targeted inhibition diminishes neuronal excitability and attenuates pain processing without disrupting other sodium channel subtypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (193.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.