CAS No. 3034880-93-5

Batch: Purity:99.70
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VVD-130037(BAY-3605349) Chemical Structure
Chemical Structure
Check the VVD-130037(BAY-3605349) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(3R)-3-[3-(4-aminopyrimidin-2-yl)-5-chlorophenyl]morpholin-4-yl]prop-2-en-1-one
CAS Number 3034880-93-5
Molecular Formula

C17H17ClN4O2
Molecular Weight (MW) 344.80
InChIKey IRLNMPCPLJZIGO-AWEZNQCLSA-N

Biological Activity

VVD-130037 (BAY-3605349) is an orally available, covalent small-molecule activator of Kelch-like ECH-associated protein 1 (KEAP1). By covalently binding KEAP1, it promotes the enhanced cellular degradation of nuclear factor erythroid 2-related factor 2 (NRF2). Attenuating NRF2 signaling disrupts downstream antioxidant and cytoprotective gene expression, impairing tumor cell survival and resulting in significant inhibition of tumor growth in advanced solid tumors. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 64 mg/mL (185.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 17 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Yamamoto M, et al. Physiol Rev. 2018;98(3):1169-1203.

[2] Kansanen E, et al. Redox Biol. 2013;1(1):45-9.

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Note: Technical data last updated: Sep 1, 2026.