CAS No. 1028327-66-3

Batch: Purity:98.98
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VUF10460 Chemical Structure
Chemical Structure
Check the VUF10460 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1028327-66-3
Molecular Formula

C15H19N5
Molecular Weight (MW) 269.34
SMILES CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC=CC=C3)N

Biological Activity

VUF10460 is a selective agonist targeting the histamine H4 receptor. Activation of the histamine H4 receptor modulates immune and inflammatory responses by inducing chemotaxis and mediating cytokine release in various immune cells, such as eosinophils, mast cells, and T lymphocytes. Through this selective receptor interaction, VUF10460 regulates downstream signaling pathways involved in allergic reactions and chronic inflammatory cascades. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 54 mg/mL (200.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 54 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Leurs R, et al. Br J Pharmacol. 2009;157(1):14-23.

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Note: Technical data last updated: Sep 1, 2026.