CAS No. 155584-74-0
| CAS Number | 155584-74-0 | |
|---|---|---|
| Molecular Formula |
C13H15ClN4 |
|
| Molecular Weight (MW) | 262.74 | |
| SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl |
VUF 10166 is a potent, competitive antagonist of the 5-HT3A receptor, displaying marked subtype selectivity compared to the heteromeric 5-HT3AB receptor complex. By selectively blocking 5-HT3 ion channels, the compound inhibits serotonin-evoked cation influx, preventing rapid cell membrane depolarization. This targeted channel inhibition disrupts downstream serotonergic signaling pathways, subsequently reducing neuronal excitability and modulating synaptic transmission within central and peripheral neural networks.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 61 mg/mL |
| DMSO |
21 mg/mL
(79.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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