CAS No. 2442597-56-8
Batch:
Purity:99.93
Chemical Structure
Check the
VU6015929
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-fluoro-3-[[5-(1-methylpyrazol-3-yl)-3-pyridinyl]methylamino]-N-[3-(trifluoromethoxy)phenyl]benzamide | |
|---|---|---|
| CAS Number | 2442597-56-8 | |
| Molecular Formula |
C24H19F4N5O2 |
|
| Molecular Weight (MW) | 485.43 | |
| SMILES | C[N]1C=CC(=N1)C2=CN=CC(=C2)CNC3=C(F)C=CC(=C3)C(=O)NC4=CC(=CC=C4)OC(F)(F)F | |
| InChIKey | IZKVIUJIUTXIRH-UHFFFAOYSA-N |
VU6015929 is a potent, selective inhibitor of discoidin domain receptor 1 (DDR1) and discoidin domain receptor 2 (DDR2). By targeting DDR1/2 kinase activity, this compound blocks collagen-activated receptor signaling and disrupts downstream extracellular matrix remodeling pathways. Consequently, DDR1/2 inhibition leads to impaired cellular interaction with matrix components and potently suppresses cellular collagen-IV production. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(201.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.