CAS No. 61350-00-3
| CAS Number | 61350-00-3 | |
|---|---|---|
| Molecular Formula |
C12H9ClN2O |
|
| Molecular Weight (MW) | 232.67 | |
| SMILES | C1=CC=NC(=C1)C(=O)NC2=CC(=CC=C2)Cl |
VU 0364770 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGlu4) with an EC50 of 1.1 μM. By selectively potentiating mGlu4 activation without significant activity at other mGlu subtypes, it modulates glutamatergic neurotransmission in the central nervous system. Activation of mGlu4 downstream signaling regulates synaptic transmission and attenuates motor deficits, demonstrating neuroprotective and functional circuit modulation in preclinical models.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(202.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 47 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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