CAS No. 1246086-78-1
Batch:
Purity:99.68
Chemical Structure
Check the
VU 0364439
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1246086-78-1 | |
|---|---|---|
| Molecular Formula |
C18H13Cl2N3O3S |
|
| Molecular Weight (MW) | 422.29 | |
| SMILES | C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl |
VU 0364439 is a potent positive allosteric modulator targeting metabotropic glutamate receptor 4 (mGlu4). Potentiation of mGlu4 enhances receptor responsiveness to endogenous glutamate, leading to presynaptic inhibition of neurotransmitter release across central glutamatergic signaling pathways. This selective allosteric modulation fine-tunes synaptic transmission and plasticity, demonstrating therapeutic potential for neurodegenerative and central nervous system disorders. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.