CAS No. 1013937-63-7
Batch:
Purity:98.48
Chemical Structure
Check the
VTP-27999 TFA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate;2,2,2-trifluoroacetic acid | |
|---|---|---|
| CAS Number | 1013937-63-7 | |
| Molecular Formula |
C28H42ClF3N4O7 |
|
| Molecular Weight (MW) | 639.1 | |
| SMILES | CNC(CC1CCCOC1)CNC(=O)N2CCCC(C2)C(C3=CC(=CC=C3)Cl)OCCNC(=O)OC.C(=O)(C(F)(F)F)O | |
| InChIKey | SYWYSVAEGXHOJO-VIEYARBJSA-N |
VTP-27999 TFA is a potent, orally active, selective alkylamine human renin inhibitor. By targeting human renin, it suppresses the renin-angiotensin-aldosterone system (RAAS), blocking the cleavage of angiotensinogen into angiotensin I. Downstream inhibition of RAAS decreases angiotensin II production, leading to reduced vasoconstriction, suppressed aldosterone secretion, and attenuated blood pressure regulation signaling pathways in cardiovascular tissues.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(156.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.