CAS No. 2506273-81-8
Batch:
Purity:99.587
Chemical Structure
Check the
VT3989
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2R)-1-hydroxypropan-2-yl]-5-[4-(trifluoromethyl)phenoxy]naphthalene-2-carboxamide | |
|---|---|---|
| CAS Number | 2506273-81-8 | |
| Molecular Formula |
C21H18F3NO3 |
|
| Molecular Weight (MW) | 389.37 | |
| InChIKey | FJIVCOAHSKDOAC-CYBMUJFWSA-N |
VT3989 is an orally bioavailable, selective inhibitor of TEAD auto-palmitoylation that blocks the interaction between TEAD transcription factors and yes-associated protein (YAP). By disrupting the Hippo signaling pathway, VT3989 suppresses YAP/TAZ-driven transcriptional activity and downstream oncogenic gene expression. This inhibition impairs cellular proliferation and demonstrates potent preclinical antitumor efficacy in models of NF2-mutant solid tumors and malignant mesothelioma. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
| Ethanol | 78 mg/mL |
| DMSO |
75 mg/mL
(192.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- VT3989 Mechanism of Action: TEAD Inhibition in Mesothelioma Cell Research
- VT3989 Clinical Trials
- VT3989 Working Concentration | Cell Culture | Treatment
- VT3989 Solubility in DMSO
- VT3989 Stock Solution
- VT3989 Storage
- VT3989 Stability
- VT3989 Molecular Weight
- VT3989 Chemical Structure (2D and 3D)
- VT3989 Sigma (TA9H9A9A9911)? Try a better option.
- VT3989 MedChemExpress (HY-400902)? Try a better option.
- VT3989 Cayman (45146)? Try a better option.
- VT3989 AdooQ (A24647)? Try a better option.
- VT3989 TargetMol (T87651)? Try a better option.
- VT3989 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.