CAS No. 1624602-30-7
Batch:
Purity:99.04
Chemical Structure
Check the
VR23
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-chloro-4-[4-(2,4-dinitrophenyl)sulfonylpiperazin-1-yl]quinoline | |
|---|---|---|
| CAS Number | 1624602-30-7 | |
| Molecular Formula |
C19H16ClN5O6S |
|
| Molecular Weight (MW) | 477.88 | |
| SMILES | C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-] | |
| InChIKey | PDQVZPPIHADUOO-UHFFFAOYSA-N |
Biological Activity
VR23 is a small-molecule proteasome inhibitor that targets the catalytic activities of the 20S proteasome complex, including trypsin-like, chymotrypsin-like, and caspase-like proteasomal active sites. By blocking the proteasomal degradation of short-lived and polyubiquitinated cellular proteins, proteasome inhibition disrupts essential protein homeostasis, induces endoplasmic reticulum stress, and promotes downstream apoptotic cell death in cancer cells.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
31 mg/mL
(64.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 5 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.