Vortioxetine

Catalog No.S5506

For research use only.

Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.

Vortioxetine Chemical Structure

CAS No. 508233-74-7

Purity & Quality Control

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Biological Activity

Description Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 34 mg/mL
(113.92 mM)
Water Insoluble
Ethanol '28 mg/mL

Chemical Information

Molecular Weight 298.45
Formula

C18H22N2S

CAS No. 508233-74-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04895488 Not yet recruiting Drug: Vortioxetine|Drug: Usual Antipsychotic Treatment Cognitive Impairment With Primary Psychotic Disorder|Negative Symptoms With Primary Psychotic Disorder Fundación Pública Andaluza para la gestión de la Investigación en Sevilla November 15 2021 Phase 2|Phase 3
NCT05014919 Recruiting Drug: Vortioxetine|Drug: Placebo Depression H. Lundbeck A/S August 10 2021 Phase 3
NCT04301492 Recruiting Drug: Vortioxetine Depression IRCCS San Raffaele January 1 2020 Phase 4
NCT02932904 Completed Drug: Vortioxetine|Drug: Paroxetine|Drug: Placebo Healthy Volunteers Takeda November 21 2016 Phase 4
NCT03978286 Completed Drug: Vortioxetine|Drug: Sertraline Depression|Type 2 Diabetes Mellitus Universidad Juárez Autónoma de Tabasco June 30 2016 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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