CAS No. 1192171-69-9

Batch: Purity:99.94
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Vonafexor (EYP001) Chemical Structure
Chemical Structure
Check the Vonafexor (EYP001) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid
CAS Number 1192171-69-9
Molecular Formula

C19H15Cl3N2O5S
Molecular Weight (MW) 489.76
SMILES C1CN(CCN1C2=C(C3=C(C=C2)OC(=C3)C(=O)O)Cl)S(=O)(=O)C4=C(C=CC=C4Cl)Cl
InChIKey XLGQSYUNOIJBNR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Vonafexor (EYP001) is a non-bile acid, selective second-generation agonist of farnesoid X receptor (FXR, NR1H4). Activation of FXR induces target gene transcription involved in bile acid homeostasis, lipid metabolism, and hepatic inflammatory responses. Through activation of nuclear receptor signaling, FXR agonists modulate transcriptional networks to reduce hepatic steatosis and inflammatory stress in liver disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (200.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.