CAS No. 139290-65-6
Batch:
Purity:99.76
Chemical Structure
Check the
Volinanserin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (R)-(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol | |
|---|---|---|
| CAS Number | 139290-65-6 | |
| Molecular Formula |
C22H28FNO3 |
|
| Molecular Weight (MW) | 373.46 | |
| SMILES | COC1=CC=CC(=C1OC)C(C2CCN(CC2)CCC3=CC=C(C=C3)F)O | |
| InChIKey | HXTGXYRHXAGCFP-OAQYLSRUSA-N |
Volinanserin (MDL-100,907) is a highly selective and potent 5-HT2 receptor antagonist with a Ki of. By inhibiting 5-HT2 receptor-mediated signaling pathways, it modulates central serotonergic neurotransmission and attenuates dopamine-driven responses. In preclinical models, volinanserin demonstrates robust antipsychotic activity, effectively blocking hyperlocomotion and behavioral deficits induced by psychotomimetic agents without inducing extrapyramidal side effects. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(200.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.