CAS No. 1388803-90-4

Batch: Purity:99.71
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Vodobatinib (K0706) Chemical Structure
Chemical Structure
Check the Vodobatinib (K0706) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-6-methyl-N'-[4-methyl-3-(2-quinolin-3-ylethynyl)benzoyl]benzohydrazide
CAS Number 1388803-90-4
Molecular Formula

C27H20ClN3O2
Molecular Weight (MW) 453.92
SMILES CC1=C(C=C(C=C1)C(=O)NNC(=O)C2=C(C)C=CC=C2Cl)C#CC3=CC4=CC=CC=C4N=C3
InChIKey ZQOBVMHBVWNVBG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Vodobatinib is a third-generation, orally active BCR-ABL1 tyrosine kinase inhibitor. In cellular assays, vodobatinib exhibits potent anti-leukemic activity by inhibiting cell proliferation in Philadelphia chromosome-positive leukemia. It retains efficacy against a broad spectrum of clinically relevant BCR-ABL1 point mutations, suppressing leukemic cell growth. However, vodobatinib lacks activity against the BCR-ABL1 T315I gatekeeper mutation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.