CAS No. 476310-60-8
| IUPAC Name | bis(3-hydroxypyridine-2-carboxylic acid);oxovanadium;trihydrate | |
|---|---|---|
| CAS Number | 476310-60-8 | |
| Molecular Formula |
C12H9N2O8V.3H2O.H |
|
| Molecular Weight (MW) | 415.20 | |
| SMILES | [H+].C1=CC(=C(N=C1)C(=O)[O-])O.C1=CC(=C(N=C1)C(=O)[O-])[O-].O.O[V]=O | |
| InChIKey | RHVLCDIRYQMAQQ-UHFFFAOYSA-N |
VO-Ohpic trihydrate is a potent, selective inhibitor of PTEN (IC50 of 35 nM). By inhibiting PTEN phosphatase activity, it prevents the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PIP3), resulting in sustained activation of the downstream PI3K/AKT signaling pathway. Consequently, VO-Ohpic promotes AKT phosphorylation and regulates downstream cellular processes including cell survival, proliferation, and glucose metabolism in preclinical cellular models.[1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(173.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
83 mg/mL
(199.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
83 mg/mL
(199.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.