CAS No. 2914879-10-8

Batch: Purity:
VLS-1488(KIF18A-IN-6 ) Chemical Structure
Chemical Structure
Check the VLS-1488(KIF18A-IN-6 ) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2914879-10-8
Molecular Formula

C28H37N3O5S2
Molecular Weight (MW) 559.74
InChIKey AXRRVVWONHGXHG-UHFFFAOYSA-N

Biological Activity

VLS-1488 is a potent oral inhibitor of KIF18A, a mitotic kinesin motor protein that localizes to the plus-ends of kinetochore microtubule spindle fibers. By disrupting KIF18A activity, it impairs chromosome alignment during mitosis, alters kinetochore microtubule dynamics, and triggers prolonged mitotic arrest followed by cell death, selectively targeting aneuploid cancer cells characterized by high chromosomal instability. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Mayr MI, et al. Curr Biol. 2007;17(6):488-98.

[2] Stumpff J, et al. Dev Cell. 2008;14(2):252-62.

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Note: Technical data last updated: Sep 1, 2026.