CAS No. 1702967-37-0

Batch: Purity:99.73
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Vipivotide tetraxetan (PSMA-617) Chemical Structure
Chemical Structure
Check the Vipivotide tetraxetan (PSMA-617) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-[[(1S)-1-carboxy-5-[[(2S)-3-naphthalen-2-yl-2-[[4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]methyl]cyclohexanecarbonyl]amino]propanoyl]amino]pentyl]carbamoylamino]pentanedioic acid
CAS Number 1702967-37-0
Molecular Formula

C49H71N9O16
Molecular Weight (MW) 1042.14
SMILES C1CC(CCC1CNC(=O)CN2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NCCCCC(C(=O)O)NC(=O)NC(CCC(=O)O)C(=O)O
InChIKey JBHPLHATEXGMQR-VLOIPPKDSA-N

Biological Activity

Vipivotide tetraxetan (PSMA-617) is a high-affinity inhibitor of prostate-specific membrane antigen (PSMA) with a Ki of 0.37 nM. By binding selectively to the extracellular domain of PSMA, it targets PSMA-expressing tumor cells and mediates rapid cellular internalization. This specific target binding impairs PSMA enzymatic activity and enables effective delivery of payload conjugates or radiolabels to prostate cancer cells.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.