CAS No. 163521-08-2

Batch: Purity:99.9
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Vilazodone HCl Chemical Structure
Chemical Structure
Check the Vilazodone HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;hydrochloride
CAS Number 163521-08-2
Molecular Formula

C26H27N5O2.HCl
Molecular Weight (MW) 477.99
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N.Cl
InChIKey RPZBRGFNBNQSOP-UHFFFAOYSA-N

Ordering Information

Biological Activity

Vilazodone HCl is a dual-acting selective serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. By simultaneously inhibiting the serotonin transporter and activating 5-HT1A autoreceptors, it increases extracellular serotonin concentrations in key brain regions. This dual mechanism enhances serotonergic neurotransmission and modulates downstream neurochemical signaling, leading to potent antidepressant-like behavioral phenotypes in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (198.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.