CAS No. 1448188-62-2
Batch:
Purity:98.08
Chemical Structure
Check the
VH032
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 1448188-62-2 | |
| Molecular Formula |
C24H32N4O4S |
|
| Molecular Weight (MW) | 472.60 | |
| InChIKey | GFVIEZBZIUKYOG-SVFBPWRDSA-N |
VH032 is a potent and selective von Hippel-Lindau (VHL) E3 ligase ligand that binds VHL with a Kd of. By binding to VHL, VH032 disrupts the interaction between VHL and HIF-α, leading to HIF-1α stabilization and activation of downstream hypoxic signaling pathways. Furthermore, VH032 serves as a key VHL-recruiting warhead for designing proteolysis targeting chimeras to drive targeted protein degradation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(201.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.