CAS No. 2738485-98-6
Batch:
Purity:99.61
Chemical Structure
Check the
VG-3927
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-2-(1-methylpyrazol-4-yl)oxan-4-yl]pyrido[3,4-b]pyrazine | |
|---|---|---|
| CAS Number | 2738485-98-6 | |
| Molecular Formula |
C24H23ClFN5O |
|
| Molecular Weight (MW) | 451.92 | |
| InChIKey | DGBQOJDFECEEKU-OYHNWAKOSA-N |
VG-3927 is a potent, selective, and brain-penetrant small-molecule agonist targeting triggering receptor expressed on myeloid cells 2 (TREM2). Activation of TREM2 enhances microglial survival, phagocytosis, and anti-inflammatory microglial signaling to promote neuroprotective phenotypes. This pathway facilitates the clearance of cellular debris and pathogenic protein aggregates, supporting microglial homeostasis in neurodegenerative conditions such as Alzheimer's disease. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(199.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.