CAS No. 1392136-43-4

Batch: Purity:99.86
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Verdinexor (KPT-335) Chemical Structure
Chemical Structure
Check the Verdinexor (KPT-335) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide
CAS Number 1392136-43-4
Molecular Formula

C18H12F6N6O
Molecular Weight (MW) 442.32
SMILES C1=CC=NC(=C1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
InChIKey OPAKEJZFFCECPN-XQRVVYSFSA-N

Ordering Information

Biological Activity

Verdinexor (KPT-335) is an orally bioavailable, selective inhibitor of exportin-1 (XPO1/CRM1). By blocking XPO1-mediated nuclear export, Verdinexor forces the nuclear retention of tumor suppressor proteins and signaling factors, disrupting critical oncogenic and viral replication pathways. This targeted inhibition suppresses cell proliferation, attenuates viral load, and induces apoptosis across preclinical models of hematologic malignancies and viral infections. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (198.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.