CAS No. 747413-08-7
| IUPAC Name | 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide | |
|---|---|---|
| CAS Number | 747413-08-7 | |
| Molecular Formula |
C19H17ClN2O5 |
|
| Molecular Weight (MW) | 388.80 | |
| SMILES | CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)OC)C3=CC(=C(C=C3O)O)Cl | |
| InChIKey | JXPCDMPJCKNLBY-UHFFFAOYSA-N |
VER-50589 is a potent heat shock protein 90 (HSP90) inhibitor that selectively targets HSP90β. By binding to HSP90, it disrupts chaperone function and compromises the conformational stability and maturation of client proteins, thereby inhibiting downstream signaling pathways essential for cellular proliferation and survival. Disruption of the HSP90 machinery leads to the degradation of multiple oncogenic client proteins, ultimately inducing cell cycle arrest and apoptosis in sensitive cancer cell models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(198.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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