CAS No. 1681017-83-3

Batch: Purity:99.76
Check CoA
Venadaparib(IDX-1197) Chemical Structure
Chemical Structure
Check the Venadaparib(IDX-1197) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[3-[3-[(cyclopropylamino)methyl]azetidine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
CAS Number 1681017-83-3
Molecular Formula

C23H23FN4O2
Molecular Weight (MW) 406.45
SMILES FC1=C(C=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1)C(=O)N4CC(CNC5CC5)C4
InChIKey YNBQAYKYNYRCCA-UHFFFAOYSA-N

Ordering Information

Biological Activity

Venadaparib (IDX-1197) acts as a potent inhibitor targeting PARP1 and PARP2. By disrupting poly(ADP-ribose) polymerase catalytic function, the compound prevents the repair of cellular DNA single-strand breaks and facilitates their conversion into toxic double-strand breaks. This persistent DNA damage suppresses genomic integrity repair mechanisms and selectively drives synthetic lethality in DNA repair-deficient cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.