CAS No. 2230186-18-0
Batch:
Purity:99.93
Chemical Structure
Check the
VB124
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[[1-(2-chlorophenyl)-5-(3-cyclopropyloxyphenyl)pyrazol-3-yl]methoxy]-2-methylpropanoic acid | |
|---|---|---|
| CAS Number | 2230186-18-0 | |
| Molecular Formula |
C23H23ClN2O4 |
|
| Molecular Weight (MW) | 426.89 | |
| SMILES | CC(C)(OCC1=N[N](C2=C(Cl)C=CC=C2)C(=C1)C3=CC(=CC=C3)OC4CC4)C(O)=O | |
| InChIKey | PZHRLEZWTVYGMP-UHFFFAOYSA-N |
Biological Activity
VB124 is a potent and selective monocarboxylate transporter 4 (MCT4) inhibitor. By targeting MCT4, it specifically inhibits lactate efflux and import in cells expressing MCT4, such as MDA-MB-231 cells, thereby disrupting intracellular lactate homeostasis and glycolytic flux. Downstream, blockade of MCT4-mediated transport alters cellular energy metabolism and attenuates pathological remodeling, serving as a valuable tool for researching cardiac hypertrophy and heart failure.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 85 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.