CAS No. 1414976-20-7
Batch:
Purity:99.84
Chemical Structure
Check the
Vazegepant hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1H-quinolin-3-yl)piperidine-1-carboxamide;hydrochloride | |
|---|---|---|
| CAS Number | 1414976-20-7 | |
| Molecular Formula |
C36H46N8O3.ClH |
|
| Molecular Weight (MW) | 675.26 | |
| InChIKey | VQDUWCSSPSOSNA-RYWNGCACSA-N |
Vazegepant hydrochloride is a potent and selective small-molecule antagonist of the calcitonin gene-related peptide (CGRP) receptor. By selectively inhibiting CGRP receptor signaling, it blocks CGRP-mediated intracellular cAMP accumulation and downstream protein kinase A activation in vascular and trigeminal neuronal tissues. This inhibition suppresses trigeminovascular neurogenic inflammation and perivascular vasodilation, thereby counteracting trigeminal pain pathway sensitization involved in headache pathogenesis. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
25 mg/mL
(37.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.