CAS No. 7174-27-8

Batch: Purity:99.54
Check CoA
Vasicine (hydrochloride) Chemical Structure
Chemical Structure
Check the Vasicine (hydrochloride) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol;hydrochloride
CAS Number 7174-27-8
Molecular Formula

C11H12N2O.ClH
Molecular Weight (MW) 224.69
InChIKey CSDQSAHJCAKJPT-PPHPATTJSA-N

Ordering Information

Biological Activity

Vasicine hydrochloride is a natural pyrroloquinazoline alkaloid and cholinesterase inhibitor that targets acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). By suppressing AChE and BChE activity, vasicine elevates synaptic acetylcholine concentrations to enhance cholinergic neurotransmission. Downstream, this regulation restores cholinergic signaling pathways and improves cognitive deficits and neuroinflammatory responses associated with neurodegenerative disorders such as Alzheimer's disease. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 45 mg/mL (200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 45 mg/mL
Ethanol 45 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.