CAS No. 224789-15-5
Batch:
Purity:99.84
Chemical Structure
Check the
Vardenafil dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one;dihydrochloride | |
|---|---|---|
| CAS Number | 224789-15-5 | |
| Molecular Formula |
C23H32N6O4S.2ClH |
|
| Molecular Weight (MW) | 561.53 | |
| InChIKey | NOIHTGOGFDFCBN-UHFFFAOYSA-N |
Vardenafil dihydrochloride is a potent and selective PDE5 inhibitor (IC50 =, exhibiting selectivity over PDE6 (IC50 = and PDE1 (IC50 =. By preventing cGMP degradation, it enhances NO/cGMP signaling, promoting smooth muscle relaxation and vascular dilation. This downstream pathway modulation supports research in erectile dysfunction, metabolic regulation, and vascular pathologies. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(178.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 25 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.