CAS No. 67469-78-7

Batch: Purity:99.14
Check CoA
Vanoxerine dihydrochloride Chemical Structure
Chemical Structure
Check the Vanoxerine dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 67469-78-7
Molecular Formula

C28H34Cl2F2N2O
Molecular Weight (MW) 523.49
SMILES C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl

Ordering Information

Biological Activity

Vanoxerine dihydrochloride (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex. By binding to the dopamine transporter, it blocks the reuptake of extracellular dopamine into presynaptic nerve terminals. This inhibition increases synaptic dopamine accumulation and enhances dopaminergic neurotransmission, modulating downstream dopamine receptor signaling and cellular responses associated with central nervous system pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 17 mg/mL (32.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 5 mg/mL
Ethanol 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.