CAS No. 55-10-7

Batch: Purity:99.85
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Vanillylmandelic acid Chemical Structure
Chemical Structure
Check the Vanillylmandelic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 55-10-7
Molecular Formula

C9H10O5
Molecular Weight (MW) 198.17
SMILES COC1=C(C=CC(=C1)C(C(=O)O)O)O

Ordering Information

Biological Activity

Vanillylmandelic acid (VMA) is a naturally occurring organic compound and a major end-stage metabolite of the catecholamines epinephrine and norepinephrine. It is generated through the sequential enzymatic degradation of catecholamines by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) in the sympathoadrenal system. As a key end product of catecholamine catabolism, vanillylmandelic acid serves as an important biomarker for evaluating sympathoadrenal function and catecholamine metabolism. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (201.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 40 mg/mL
Ethanol 40 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.