CAS No. 121-34-6
Batch:
Purity:99.78
Chemical Structure
Check the
Vanillic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-hydroxy-3-methoxybenzoic acid | |
|---|---|---|
| CAS Number | 121-34-6 | |
| Molecular Formula |
C8H8O4 |
|
| Molecular Weight (MW) | 168.15 | |
| SMILES | COC1=C(C=CC(=C1)C(=O)O)O | |
| InChIKey | WKOLLVMJNQIZCI-UHFFFAOYSA-N |
Vanillic acid is a naturally occurring phenolic acid and flavoring agent that acts as an inhibitor of NF-κB activation. By blocking NF-κB signaling pathways, it downregulates the production of pro-inflammatory mediators including TNF-α and IL-6. These molecular actions contribute to its broad biological spectrum, which includes potent anti-inflammatory, antibacterial, and chemopreventive activities against oxidative stress and inflammatory injury. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
33 mg/mL
(196.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.