CAS No. 56124-62-0

Batch: Purity:99.67
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Valrubicin Chemical Structure
Chemical Structure
Check the Valrubicin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[(2R,4S,5S,6S)-5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate
CAS Number 56124-62-0
Molecular Formula

C34H36F3NO13
Molecular Weight (MW) 723.64
SMILES CCCCC(=O)OCC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)OC5CC(C(C(O5)C)O)NC(=O)C(F)(F)F)O
InChIKey ZOCKGBMQLCSHFP-KQRAQHLDSA-N

Ordering Information

Biological Activity

Valrubicin (AD-32) is a chemotherapy agent that inhibits TPA-induced PKC activation (IC50 of 0.85 μM) and PDBu-induced PKC activation (IC50 of 1.25 μM). By suppressing protein kinase C (PKC) signaling pathways and inducing DNA damage through topoisomerase II inhibition, it blocks downstream cellular proliferation and survival mechanisms. This disruption impairs tumor cell viability and promotes apoptotic responses in malignant cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (138.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.