CAS No. 1025504-45-3
Batch:
Purity:99.45
Chemical Structure
Check the
Valbenazine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate | |
|---|---|---|
| CAS Number | 1025504-45-3 | |
| Molecular Formula |
C24H38N2O4 |
|
| Molecular Weight (MW) | 418.57 | |
| InChIKey | GEJDGVNQKABXKG-CFKGEZKQSA-N |
Valbenazine is a potent and selective vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki of 110–190 nM. By inhibiting VMAT2, it disrupts the uptake of monoamines into presynaptic vesicles, leading to reduced monoamine storage and depleted presynaptic dopamine release. This selective reduction in synaptic dopamine levels modulates striatal neurotransmission and attenuates hyperkinetic movement phenotypes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 28 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 42 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.