CAS No. 1639208-54-0

Batch: Purity:98.63
Check CoA
Valbenazine tosylate Chemical Structure
Chemical Structure
Check the Valbenazine tosylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate;bis(4-methylbenzenesulfonic acid)
CAS Number 1639208-54-0
Molecular Formula

C38H54N2O10S2
Molecular Weight (MW) 762.97
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
InChIKey BXGKAGLZHGYAMW-TZYFFPFWSA-N

Ordering Information

Biological Activity

Valbenazine tosylate is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM, displaying minimal affinity for VMAT1. By inhibiting VMAT2, it selectively impairs presynaptic monoamine uptake into storage vesicles, resulting in reduced synaptic dopamine levels. This depletion dampens striatal dopaminergic neurotransmission and attenuates downstream motor activity, thereby modulating basal ganglia function and hyperkinetic movement phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (131.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 25 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.