CAS No. 1357362-02-7
Batch:
Purity:98.59
Chemical Structure
Check the
Vafidemstat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine | |
|---|---|---|
| CAS Number | 1357362-02-7 | |
| Molecular Formula |
C19H20N4O2 |
|
| Molecular Weight (MW) | 336.39 | |
| InChIKey | XBBRLCXCBCZIOI-DLBZAZTESA-N |
Biological Activity
Vafidemstat (ORY-2001) is a brain-penetrant dual inhibitor targeting lysine-specific histone demethylase 1 (LSD1, KDM1A) and monoamine oxidase B (MAO-B). Inhibition of LSD1 and MAO-B modulates histone demethylation and chromatin remodeling pathways, regulating epigenetic gene transcription in the brain. These downstream epigenetic modifications modulate neuroinflammatory signaling, helping rescue cognitive deficits and restore behavioral functions in preclinical models of neurodegenerative disorders. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
22 mg/mL
(65.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.