CAS No. 1855871-76-9

Batch: Purity:99.99
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V-9302 Chemical Structure
Chemical Structure
Check the V-9302 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
CAS Number 1855871-76-9
Molecular Formula

C34H38N2O4
Molecular Weight (MW) 538.68
SMILES CC1=CC(=CC=C1)COC2=CC=CC=C2CN(CCC(C(=O)O)N)CC3=CC=CC=C3OCC4=CC=CC(=C4)C
InChIKey YGKNVAAMULVFNN-HKBQPEDESA-N

Ordering Information

Biological Activity

V-9302 is a competitive small-molecule antagonist of transmembrane glutamine flux that selectively targets amino acid transporter ASCT2 (SLC1A5) with an IC50 offor glutamine uptake inhibition in HEK-293 cells. Blockade of ASCT2-mediated transport attenuates downstream mTORC1 pathway signaling, elevates intracellular reactive oxygen species and oxidative stress, and impairs tumor cell proliferation while inducing apoptotic cell death. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (185.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.