CAS No. 2756566-45-5
Batch:
Purity:99.47
Chemical Structure
Check the
UZH2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | |
|---|---|---|
| CAS Number | 2756566-45-5 | |
| Molecular Formula |
C27H37F2N7O |
|
| Molecular Weight (MW) | 513.63 | |
| InChIKey | GYWOVBUGFWWSJR-UHFFFAOYSA-N |
UZH2 is a potent and selective inhibitor of METTL3 with an IC50 value of 5 nM in a TR-FRET assay. By inhibiting the METTL3/METTL14 RNA methyltransferase complex, UZH2 demonstrates intracellular target engagement and significantly reduces N6-methyladenosine (m6A) levels in polyadenylated RNA, thereby impairing m6A-mediated epitranscriptomic signaling in acute myeloid leukemia and prostate cancer cell lines. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(25.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.