CAS No. 646530-37-2
Batch:
Purity:99.75
Chemical Structure
Check the
UTL-5g
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide | |
|---|---|---|
| CAS Number | 646530-37-2 | |
| Molecular Formula |
C11H8Cl2N2O2 |
|
| Molecular Weight (MW) | 271.1 | |
| SMILES | CC1=CC(=NO1)C(=O)NC2=CC=C(Cl)C=C2Cl | |
| InChIKey | ULPKSWAQDCJLMN-UHFFFAOYSA-N |
UTL-5g is a small-molecule TNF-α inhibitor that functions as an effective chemoprotective agent against drug-induced organ toxicities. By suppressing TNF-α-mediated inflammatory signaling pathways and apoptotic cascades, UTL-5g reduces downstream cellular damage. In preclinical models, UTL-5g significantly lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by cisplatin, mitigating severe adverse side effects without compromising therapeutic efficacy.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.