CAS No. 1381291-36-6
Batch:
Purity:99.64
Chemical Structure
Check the
USP7-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-chloro-3-[[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl]quinazolin-4-one | |
|---|---|---|
| CAS Number | 1381291-36-6 | |
| Molecular Formula |
C23H24ClN3O3 |
|
| Molecular Weight (MW) | 425.91 | |
| InChIKey | CITWIBXKKHFDFM-UHFFFAOYSA-N |
USP7-IN-1 functions as a selective and reversible inhibitor of ubiquitin-specific-processing protease 7 (USP7). By inhibiting the deubiquitinating activity of USP7, this compound disrupts the regulation of the MDM2/p53 pathway, promoting p53-mediated signaling cascades. This inhibition impairs downstream cellular survival mechanisms, resulting in significant antiproliferative effects and reduced cell viability in colorectal cancer cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(199.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.