CAS No. 2898-95-5

Batch: Purity:98.83
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Ursodeoxycholic acid sodium Chemical Structure
Chemical Structure
Check the Ursodeoxycholic acid sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
CAS Number 2898-95-5
Molecular Formula

C24H40O4.Na
Molecular Weight (MW) 414.55
SMILES [Na+].CC(CCC([O-])=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
InChIKey WDFRNBJHDMUMBL-FUXQPCDDSA-M

Biological Activity

Ursodeoxycholic acid sodium is a hydrophilic bile acid derivative that acts as a cytoprotective agent by modulating mitochondrial stability and signaling pathways. It suppresses the activation of NF-κB and MAPK pathways, decreasing phosphorylation of ERK, JNK, and p38 to attenuate pro-inflammatory cytokine expression. Furthermore, it preserves mitochondrial membrane integrity to block cytochrome c release and inhibit intrinsic apoptotic cascades.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 83 mg/mL
Ethanol 83 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Ko WK, et al. Mol Neurobiol. 2019;56(1):267-277.

[2] Rodrigues CM, et al. Cell Death Differ. 1999;6(9):842-854.

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Note: Technical data last updated: Sep 1, 2026.