CAS No. 1139-83-9
Batch:
Purity:99.93
Chemical Structure
Check the
Urolithin B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-hydroxybenzo[c]chromen-6-one | |
|---|---|---|
| CAS Number | 1139-83-9 | |
| Molecular Formula |
C13H8O3 |
|
| Molecular Weight (MW) | 212.20 | |
| SMILES | OC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)O2 | |
| InChIKey | WXUQMTRHPNOXBV-UHFFFAOYSA-N |
Urolithin B is a gut microbial metabolite and regulator of skeletal muscle mass that inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα. It suppresses the phosphorylation of JNK, ERK, and Akt while enhancing the phosphorylation of AMPK. Through modulating these AKT/mTOR and MAPK pathways, Urolithin B attenuates inflammatory signaling, promotes protein synthesis, and protects against muscle wasting.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(197.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.