CAS No. 590368-25-5

Batch: Purity:99.21
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Upamostat (WX-671) Chemical Structure
Chemical Structure
Check the Upamostat (WX-671) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name ethyl 4-[(2S)-3-[3-[(E)-(hydroxyhydrazinylidene)methyl]phenyl]-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propanoyl]piperazine-1-carboxylate
CAS Number 590368-25-5
Molecular Formula

C32H47N5O6S
Molecular Weight (MW) 629.81
SMILES CCOC(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=N)NO)N[S](=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C
InChIKey CYCFEEXTLQGJEL-XEOXDSMQSA-N

Ordering Information

Biological Activity

Upamostat (WX- is an orally bioavailable prodrug and serine protease inhibitor targeting the urokinase-type plasminogen activator (uPA) system. Following metabolic conversion to its active metabolite WX-UK1, it suppresses the uPA-mediated plasminogen activation cascade activity. Downstream, this catalytic blockade reduces extracellular matrix degradation and cellular motility, resulting in inhibited tumor cell invasion, suppressed primary tumor growth, and decreased metastatic dissemination. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (158.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.