CAS No. 3051784-94-9
Batch:
Purity:99.40
Chemical Structure
Check the
UNC9426
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-[3,5-bis(trifluoromethyl)anilino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol | |
|---|---|---|
| CAS Number | 3051784-94-9 | |
| Molecular Formula |
C32H34F6N6O |
|
| Molecular Weight (MW) | 632.64 | |
| InChIKey | CPWDPNAAVHWMCG-UHFFFAOYSA-N |
UNC9426 is an orally bioavailable small-molecule inhibitor targeting the receptor tyrosine kinase TYRO3. Inhibition of TYRO3 disrupts ligand-induced receptor phosphorylation and downregulates downstream oncogenic and immunomodulatory signaling pathways. Consequently, UNC9426 effectively suppresses TYRO3-mediated signaling cascades in tumor cells and macrophages while reducing platelet aggregation without prolonging bleeding time in functional cellular models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(15.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(158.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.